abstract：:The interconnectivity between brain development and the immune system has become an area of interest for many neuroscientists. However, to date, a limited number of known immune mediators of the peripheral nervous system (PNS) have been found to influence the development of the central nervous system (CNS). FOXP3 is a...

journal_title：Neuroscience

authors： Taylor MR,Roby CR,Elziny S,Duricy E,Taylor TM,Bowers JM

更新日期：2020-08-21 00:00:00

abstract：:Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells ("spike-timing-dependent plasticity; STDP") is cruci...

journal_title：Neuroscience

authors： Fuenzalida M,Chiu CQ,Chávez AE

更新日期：2020-08-20 00:00:00

abstract：:In contrast to other rhythmic tasks such as running, the preferred movement rate in cycling does not minimize energy consumption. It is possible that neurophysiological mechanisms contribute to the choice of cadence, however this phenomenon is not well understood. Eleven participants cycled at a fixed workload of 125 ...

journal_title：Neuroscience

authors： Sidhu SK,Lauber B

更新日期：2020-08-10 00:00:00

abstract：:Vascular endothelial cells were activated during acute ischemic brain injury, which could induce neural progenitor cell proliferation and migration. However, the mechanism was still unknown. In the current study, we explored whether vascular endothelial cells promoted neural progenitor cell proliferation and whether m...

journal_title：Neuroscience

authors： Zhou S,Gao B,Sun C,Bai Y,Cheng D,Zhang Y,Li X,Zhao J,Xu D

更新日期：2020-08-10 00:00:00

abstract：:The cerebellum harbors a specialized area on the roof of the fourth ventricle that is composed of glial cells and neurons that interface with the cerebrospinal fluid. This region includes the so-called ventromedial cord (VMC), which is composed of cells that are glial fibrillary acidic protein (GFAP)-positive and nest...

journal_title：Neuroscience

authors： Becerra-González M,Varman Durairaj R,Ostos Valverde A,Gualda EJ,Loza-Alvarez P,Portillo Martínez W,Gómez-González GB,Buffo A,Martínez-Torres A

更新日期：2020-07-15 00:00:00

abstract：:A new mammalian neuromuscular preparation is introduced for physiology and microscopy of all sorts: the intrinsic muscle of the mouse ear. The great utility of this preparation is demonstrated by illustrating how it has permitted us to develop a wholly new technique for staining muscle T-tubules, the critical conducti...

journal_title：Neuroscience

authors： Heuser JE,Tenkova TI

更新日期：2020-07-15 00:00:00

abstract：:Gambierol is a marine polycyclic ether toxin, first isolated from cultured Gambierdiscus toxicus dinoflagellates collected in French Polynesia. The chemical synthesis of gambierol permitted the analyses of its mode of action which includes the selective inhibition of voltage-gated K+ (KV) channels. In the present stud...

journal_title：Neuroscience

authors： Molgó J,Schlumberger S,Sasaki M,Fuwa H,Louzao MC,Botana LM,Servent D,Benoit E

更新日期：2020-07-15 00:00:00

abstract：:Remyelination is common under physiological conditions and usually occurs as a response to a pathological demyelinating event. Its potentiation is an important goal for the development of therapies against pathologies such as multiple sclerosis and white matter injury. Visualization and quantification in vivo of demye...

journal_title：Neuroscience

authors： Cisneros-Mejorado AJ,Garay E,Ortiz-Retana J,Concha L,Moctezuma JP,Romero S,Arellano RO

更新日期：2020-07-15 00:00:00

abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...

journal_title：Neuroscience

authors： Pizzarelli R,Griguoli M,Zacchi P,Petrini EM,Barberis A,Cattaneo A,Cherubini E

更新日期：2020-07-15 00:00:00

abstract：:This mini-review starts with a summary of the crucial contributions Ricardo Miledi made to our understanding of how the action potential triggers fast, synchronous transmitter release. It then transitions to the discovery of synaptotagmin and its role as the exocytotic Ca2+ sensor at nerve terminals. The final section...

journal_title：Neuroscience

authors： Gundersen CB

更新日期：2020-07-15 00:00:00

abstract：:The investigation on neurotransmission function during normal and pathologic development is a pivotal component needed to understand the basic mechanisms underlying neurodevelopmental pathologies. To study these diseases, many animal models have been generated which allowed to face the limited availability of human ti...

journal_title：Neuroscience

authors： Ruffolo G,Cifelli P,Miranda-Lourenço C,De Felice E,Limatola C,Sebastião AM,Diógenes MJ,Aronica E,Palma E

更新日期：2020-07-15 00:00:00

abstract：:Excessive expression of vascular endothelial growth factor (VEGF) is a common cause of blood-brain barrier (BBB) breakdown that triggers severe complications following traumatic brain injury (TBI). It has been shown that inhibition of VEGF activities may attenuate cerebral edema in pathological conditions. Vascular en...

journal_title：Neuroscience

authors： Zhou Z,Gao S,Li Y,Peng R,Zheng Z,Wei W,Zhao Z,Liu X,Li L,Zhang J

更新日期：2020-07-01 00:00:00

abstract：:White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly, and cause damage to neurological and psychological functions. Remyelination often fails because of the limited recruitment of oligodendrocyte progenitor cells (OPCs) to the demyelinated site or the inefficient differentiation of...

journal_title：Neuroscience

authors： Du B,Liang M,Zheng H,Fan C,Zhang H,Lu X,Du Z,Lian Y,Zhang Y,Bi X

更新日期：2020-07-01 00:00:00

abstract：:Mutations in γ-aminobutyric acid A receptor (GABAA) subunits and sodium channel genes, especially GABRG2 and SCN1A, have been reported to be associated with febrile seizures (FS) and genetic epilepsy with febrile seizures plus (GEFS+). GEFS+ is a well-known family of epileptic syndrome with autosomal dominant inherita...

journal_title：Neuroscience

authors： Li X,Guo S,Liu K,Zhang C,Chang H,Yang W,Rong S,Hu Q,Cui J,Wang F,Sun T

更新日期：2020-07-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced ne...

journal_title：Neuroscience

authors： Nicolini C,Michalski B,Toepp SL,Turco CV,D'Hoine T,Harasym D,Gibala MJ,Fahnestock M,Nelson AJ

更新日期：2020-06-15 00:00:00

abstract：:Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause glucocorticoid (GC) resistance. In the present study, we aimed to investi...

journal_title：Neuroscience

authors： Alhaddad H,Gordon DM,Bell RL,Jarvis EE,Kipp ZA,Hinds TD Jr,Sari Y

更新日期：2020-06-15 00:00:00

abstract：:Individuals respond faster to presentations of bisensory stimuli (e.g. audio-visual targets) than to presentations of either unisensory constituent in isolation (i.e. to the auditory-alone or visual-alone components of an audio-visual stimulus). This well-established multisensory speeding effect, termed the redundant ...

journal_title：Neuroscience

authors： Shaw LH,Freedman EG,Crosse MJ,Nicholas E,Chen AM,Braiman MS,Molholm S,Foxe JJ

更新日期：2020-06-01 00:00:00

abstract：:Cerebral ischemia/reperfusion (I/R) usually leads to the exacerbation of brain injury. In the present research, the effect of BTB and CNC homology 1 (BACH1) on cerebral I/R injury was studied. Mice model of middle cerebral artery occlusion/reperfusion (MCAO/R) and Neuro-2a (N2a) cell model of oxygen-glucose deprivatio...

journal_title：Neuroscience

authors： Yu S,Zhai J,Yu J,Yang Q,Yang J

更新日期：2020-06-01 00:00:00

abstract：:Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD specific E3 ubiquitin protein ligase 2 (smurf2). With age smurf2 expression increases and Smurf2...

journal_title：Neuroscience

authors： Sasik MUT,Eravsar ETK,Kinali M,Ergul AA,Adams MM

更新日期：2020-06-01 00:00:00

abstract：:Professional Pingju actors have been shown to exhibit practice-induced plastic changes in spontaneous regional brain activity; however, whether these changes are present in resting-state regional cerebral blood flow (CBF) remains largely unclear. Here, twenty professional Pingju opera actors and 20 age-, sex-, and han...

journal_title：Neuroscience

authors： Zhao F,Zhang W,Zhu D,Wang X,Qin W,Liu F

更新日期：2020-06-01 00:00:00

abstract：:Long non-coding RNA MALAT1 was previously revealed to express abnormally in animal and cellular models of stroke, suggesting its indispensable role in stroke. The aims of the present study were to further investigate the functions of MALAT1 and to elucidate the underlying molecular mechanisms. Oxygen glucose deprivati...

journal_title：Neuroscience

authors： Gao C,Zhang CC,Yang HX,Hao YN

更新日期：2020-05-21 00:00:00

abstract：:Fetal alcohol spectrum disorders (FASD) constitute a prevalent, yet preventable, developmental disorder worldwide. While a wealth of research demonstrates that altered function of hippocampus (HPC) and prefrontal cortex may underlie behavioral impairments in FASD, only one published paper to date has examined the impa...

journal_title：Neuroscience

authors： Gursky ZH,Spillman EC,Klintsova AY

更新日期：2020-05-21 00:00:00

abstract：:Here we investigated effects of intramuscular (i.m.) heating-needle stimulation on persistent muscle nociception evoked by i.m. injection of different doses (50-200 µl) of complete Freund's adjuvant (CFA) in rats. Paw withdrawal reflexes evoked by noxious mechanical and heat stimulation as well as hind limb swelling w...

journal_title：Neuroscience

authors： Lei J,Ye G,Pertovaara A,You HJ

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:The spontaneous action potential of isolated sinoatrial node (SAN) cells is regulated by a coupled-clock system of two clocks: the calcium clock and membrane clock. However, it remains unclear whether calcium clock inhibitors have a direct effect on the membrane clock. The purpose of this study was to investi...

journal_title：Neuroscience

authors： Chen Q,Chen JQ,Zhu PL,Wu HL,Xie XT,Dong Y,Xiang GJ,Chen MY,Li Y,Zhang JC

更新日期：2020-05-01 00:00:00

abstract：:Sleep deprivation (SD) is a common issue in today's society. Sleep is essential for proper cognitive functions, including learning and memory. Furthermore, sleep disorders can alter pain information processing. Meanwhile, hippocampal nicotinic receptors have a role in modulating pain and memory. The goal of this study...

journal_title：Neuroscience

authors： Javad-Moosavi BZ,Nasehi M,Vaseghi S,Jamaldini SH,Zarrindast MR

更新日期：2020-05-01 00:00:00

abstract：:In the olfactory system, the endocannabinoid system (ECS) regulates sensory perception and memory. A major structure involved in these processes is the anterior piriform cortex (aPC), but the impact of ECS signaling in aPC circuitry is still scantly characterized. Using ex vivo patch clamp experiments in mice and neur...

journal_title：Neuroscience

authors： Terral G,Varilh M,Cannich A,Massa F,Ferreira G,Marsicano G

更新日期：2020-05-01 00:00:00

abstract：:The fact that neurobiological research is reliant upon laboratory-reared rodents is well known. The following paper discusses this topic broadly, but also aims to highlight other species used in the study of the nervous system and the evolution of animal species usage from the end of World War II through recent invest...

journal_title：Neuroscience

authors： Żakowski W

更新日期：2020-05-01 00:00:00

abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

journal_title：Neuroscience

authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

更新日期：2020-04-30 00:00:00

abstract：:Accumulating evidence indicates a positive effect of abacus-based mental calculation (AMC) training on various cognitive functions including short-term memory (STM). Our previous work has shown AMC training-induced activation changes in the frontal-parietal network (FPN) using task fMRI. However, whether AMC training-...

journal_title：Neuroscience

authors： Zhou H,Geng F,Wang T,Wang C,Xie Y,Hu Y,Chen F

更新日期：2020-04-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron loss and gliosis in the spinal cord, brain stem and cortex. The Notch signaling pathway has been reported to be dysfunctional in neurodegenerative diseases, including ALS. However, the exact mechanism is still uncle...

journal_title：Neuroscience

authors： Liu C,Li D,Lv C,Gao Z,Qi Y,Wu H,Tian Y,Guo Y

更新日期：2020-04-15 00:00:00

abstract：:Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic stimulation overcomes these limitations by offering adva...

journal_title：Neuroscience

authors： Ye H,Chen VC,Helon J,Apostolopoulos N

更新日期：2020-04-15 00:00:00

abstract：:The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to minute quantities of GABAA receptor agonists, induces a state of general anesthesia. In addition to immobility and analgesia this state is accompanied by widespread suppression of neural activity in the cerebral cortex ...

journal_title：Neuroscience

authors： Lellouche Y,Minert A,Schreiber C,Aroch I,Vaso K,Fishman Y,Devor M

更新日期：2020-04-15 00:00:00

abstract：:Prestin (SLC26a5) is an integral membrane motor protein in outer hair cells (OHC) that underlies cochlear amplification. As a voltage-dependent protein, it relies on intrinsic sensor charge to respond to transmembrane voltage (receptor potentials), thereby effecting conformational changes. The protein's electromechani...

journal_title：Neuroscience

authors： Zhai F,Song L,Bai JP,Dai C,Navaratnam D,Santos-Sacchi J

更新日期：2020-04-01 00:00:00

abstract：:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes ...

journal_title：Neuroscience

authors： Muraoka T,Kurtzer I

更新日期：2020-04-01 00:00:00

abstract：:Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study ...

journal_title：Neuroscience

authors： Dong J,Lu C,Chen C,Li H,Liu X,Mei L

更新日期：2020-03-15 00:00:00

abstract：:Repeated induction of a temporary threshold shift (TTS) may result in a permanent threshold shift (PTS) and is thought to be associated with early onset of age-related hearing loss (ARHL). The possibility that a PTS might be induced by administration of repeated TTS-inducing noise exposures (NEs) over a short period d...

journal_title：Neuroscience

authors： Luo Y,Qu T,Song Q,Qi Y,Yu S,Gong S,Liu K,Jiang X

更新日期：2020-03-01 00:00:00

abstract：:Regular physical exercise has been described as a good strategy for prevention or reduction of musculoskeletal pain. The Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) has been investigated as a promising target for the control of inflammatory pain. Therefore, the aim of this study was to evaluate whether ac...

journal_title：Neuroscience

authors： de Azambuja G,Botasso Gomes B,Messias LHD,Aquino BM,Jorge CO,Manchado-Gobatto FB,Oliveira-Fusaro MCG

更新日期：2020-02-10 00:00:00

abstract：:Drinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of ...

journal_title：Neuroscience

authors： Ieraci A,Herrera DG

更新日期：2020-02-10 00:00:00

abstract：:Hyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system thes...

journal_title：Neuroscience

authors： Duron J,Monconduit L,Avan P

更新日期：2020-02-01 00:00:00